华盛顿大学医学院首次确定一种名为”Slc12a8”基因，可快速、直接地将NMN运输至细胞内，并调节肠道中NAD+的水平。

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美国梅奥医学中心发现，衰老过程中NAD+及其前体 NMN 水的下降或跟一种名为 CD38的蛋白质含量密切相关。

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截屏2022-01-07 下午5.22.52

宾夕法尼亚大学科学家首次鉴定出一种被命名为SLC25A51的蛋白，是协助NAD+进入人类细胞内部线粒体的关键转运蛋白。

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截屏2022-01-07 下午5.04.52

Researchers utilize an NAD+ precursor to improve oocyte health in obese mice, boost NAD+ levels, and minimize oxidative stress. 

sperm-egg-cell

An NAD+ precursor is used by researchers to promote oocyte health, increase NAD+ levels, and reduce oxidative stress in obese mice.

Injury to lung cells that extract oxygen from air shuts down their proliferative abilities, which can be alleviated by nicotinamide mononucleotide (NMN).

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Satisfied,Calm,Businessman,Taking,Break,To,Relax,Finished,Work,Sitting

Nicotinamide mononucleotide (NMN), a nicotinamide adenine dinucleotide (NAD+) precursor, effectively alleviates lung cell senescence in mice.

其他

Scientists uncover blood metabolic byproducts as signs of aging that may provide targets for age-related disease prevention through supplementation.

red-blood-cells

Researchers find blood metabolite markers indicative of aging and age-related diseases which may translate to identifying therapeutic supplement targets.

基础研究

Back to back research papers show CD38 enzymes on immune cells driving age-related decline of the critical molecule.

cd38

CD38

Two recent studies published in Nature Metabolism indicate CD38 enzymes on M1 macrophages consume NAD+ and NMN leading to progressive NAD+ level reductions with age.

CD38 Enzymes on Immune Cells Drive NAD+ Decline

Researchers review evidence supporting the importance of how nicotinamide adenine dinucleotide (NAD+) is distributed to different cell structures in health, disease, and aging.

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Creative image of embryonic stem cells

Researchers review NAD+ distribution between cellular structures in health, disease, and aging. Future discoveries in NAD+ biology will come from scientists with distinct skill sets.

Subdivision of NAD+ is Critical to Mammalian Life | NMN

Scientists repurposed a blood cancer treatment using genetically modified immune cells called CAR T cells to reverse age-associated tissue damage.

blood-cancer

A cellular therapy typically used against blood cancer called CAR T therapy improved tissue health by destroying senescent cells in mice.

华盛顿大学首次发现可运输“抑衰分子”的关键物质

抑衰之路新发现〡《自然代谢》：CD38蛋白决定体内NAD+的下降程度

宾大科学家首次鉴定出一种协助NAD+进入人体线粒体的关键蛋白

NAD+ Booster Improves Oocyte Quality

NMN Limits Senescence of Vital Lung Cells

Fluctuating Molecule Levels in the Blood May Indicate Signs of Aging

CD38 Enzymes on Immune Cell Surfaces Drive Declining NAD+ Levels with Age

The Cell Compartment Subdivision of NAD+ is Critical to Mammalian Life

Blood Cancer Therapy May Provide a Strategy for Age-Related Disease Treatments