Research reveals that long-term spermidine treatment does not increase the lifespan of middle-aged rats but increases their healthspan by lowering neuroinflammation and reducing anxiety. 


brain-2

brain

Study shows that fisetin clears damaged mitochondria and mitigates oxidative stress in rats with sepsis, limiting neuroinflammation and preserving cognitive function. 

puzzle

Fisetin may clear damaged mitochondria and reduce oxidative stress in sepsis rats, reducing neuroinflammation and preserving cognitive function.

Rats fed a processed diet high in refined carbohydrates have memory problems, which can be prevented by supplementing with an omega-3 called DHA. 

omega-3-oil-1

omega-3-oil (1)

Supplementation with the Omega 3 fatty acid DHA lowers proinflammatory gene activation to restore memory formation in rats fed a diet with processed foods.

By looking at secreted sacs from brain cells in blood, UCSF School of Medicine researchers find abnormal levels of mitochondrial and NAD+ metabolism proteins tied to major depressive disorder.

depressedmansittingheadinhandsonthestairsin

Depressed,Man,Sitting,Head,In,Hands,On,The,Stairs,In

Scientists from the University of California, San Francisco find abnormal levels of mitochondrial and NAD+-metabolism proteins linked to major depressive disorder.

Neurodegeneration

Study supports using resveratrol as a nutraceutical agent against neurodegeneration and Alzheimer’s disease

resveratrol-alzheimers-mice

Study suggests resveratrol administration may protect against neurodegeneration and improve cognition in Alzheimer's mice fed a high-fat diet.

Autoimmune brain inflammation quelled with nicotinamide adenine dinucleotide (NAD+) treatment

neuron-multiple-sclerosis

Nicotinamide adenine dinucleotide (NAD+) treatment of rats with experimental autoimmune encephalomyelitis improved signs and symptoms of the disease.

How NAD+ May Alleviate Multiple Sclerosis in Mice

Scientists restore eyesight in mice with glaucoma and age-related visual impairment by delivering youth-promoting genes. 

senior-eye-human

Harvard scientists restore eyesight in eye cells of mice with glaucoma and age-related vision loss by delivering embryonic genes.

How Genes Affect Vision in Old Age

Epigenetics

ISRIB reversed age-related spatial learning and memory deficits.

neuron

An experimental drug called ISRIB restores spatial learning and memory deficits in aged mice.

Rejuvenating Neuron Function and Cognition in Aged Mice

The addition of Disarm's promising programs for axonal degeneration expands Eli Lilly and Company’s R&D efforts in pain and neurodegeneration.

medicine-doctor-team-meeting-and-analysis-diagnose-checking-brain-testing-result-with-modern-virtual-screen-interface-on-laptop-with-stethoscope-in-hand-medical-technology-network-connection-concept

Medicine doctor team meeting and analysis. Diagnose checking brain testing result with modern virtual screen interface on laptop with stethoscope in hand, Medical technology network connection concept.

Eli Lilly acquires Disarm Therapeutics, a pharmaceutical company with programs to counter axonal degeneration and neurodegeneration.

Lilly Acquires Disarm Therapeutics | NMN

Investigators propose that a newly revealed nicotinamide adenine dinucleotide (NAD+) binding site of Sarm1 may be a promising drug target.

neuron-cell

neuron cell.

NAD+ binding to a region of the Sarm1 protein suppresses Sarm1 activity in promoting the degeneration of neurons.

Spermidine Improves Brain Inflammation and Anxiety

Fisetin Alleviates Cognitive Dysfunction and Brain Inflammation

Omega-3 Improves Memory Deficits From Processed Diet

Study Links Depression to Reduced Levels of NAD+-Producing Protein

Resveratrol Restores Cognition (In Mice with Alzheimer’s)

NAD+ Allays Multiple Sclerosis in Mice

Reversing Age-Related Vision Loss with Embryonic Gene Delivery

Drug Rejuvenates Neuron Function and Cognition in Aged Mice

Lilly Lands Disarm Therapeutics and NAD+ Metabolism Drug to Fight Neurological Diseases

NAD+ Binds to and Inhibits a Neuron Degeneration-Promoting Protein