《自然通信》发表的文章称，激活SIRT6蛋白可延长约30%的寿命，并提高身体机能，改善虚弱状态。

ilan-university

ilan university

美国百年（1912-2012）内奥运参赛选手的数据分析证实：高强度的运动训练有助于降低心血管疾病和癌症的发生风险，使运动员的寿命比普通人群长五年。

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太空旅行期间，地球磁场波动会增强宇航员的心电活动和昼夜节律，改善睡眠质量和心血管健康。

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截屏2022-01-07 下午3.50.42

衰老与寿命

A longevity-promoting gut bacteria improves bone and brain aging in mice and increases lifespan and healthspan in flies and worms.


intestinal-bacteria

Study identifies a gut microbe strain with potential as a longevity-promoting and anti-aging probiotic.

Kat7 gene inactivation rejuvenates prematurely aging human cells and mice and promotes longevity.

genetic-manipulation-and-dna-modification-concept

Genetic manipulation and DNA modification concept.

CRISPR-induced KAT7 gene inactivation rejuvenates prematurely aging human cells and mice and promotes longevity.

Changes in the body that come from space travel resemble growing older, providing opportunities to perform aging studies on astronauts.

astronaut-aging-in-space

Spending time in outer space can mimic the effects of aging, and scientists have begun using the unique environment of space as a place to study aging.

Space Travel (How Does It Affect Aging?) - NAD.com

Limited rapamycin exposure late in life was as effective as continuous exposure in increasing survival in males but not females

rapamycin

Late-life rapamycin administration regimens enhance mouse lifespan in a sex-dependent manner with limited exposure more effective in males than females.

A study from UPenn scientists shows rapamycin prevents age-related alterations of metabolic state in muscle cells, which may extend lifespan.

structure-of-the-atp-synthase-a-molecular-machine

Structure of the ATP synthase, a molecular machine

Rapamycin increases the NAD+/NADH ratio and subsequent metabolic balance by reducing NADH levels in mouse muscle.

Genetically modified mouse cells with artificial activation of a nicotinamide adenine dinucleotide (NAD+) regulating enzyme are protected from cessation of cell proliferation induced by stress, maintaining healthy aging.

stem-cells

Artificially-activated Nampt enzyme promotes cellular protection from stress-induced cessation of cell proliferation.

Enzyme Regulating NAD+ Facilitates Cell Replication 

Scientists repurposed a blood cancer treatment using genetically modified immune cells called CAR T cells to reverse age-associated tissue damage.

blood-cancer

A cellular therapy typically used against blood cancer called CAR T therapy improved tissue health by destroying senescent cells in mice.

以色列巴伊兰大学新突破：激活SIRT6蛋白可延长小鼠寿命30%

《英国运动医学杂志》研究显示：美国奥运选手的寿命比普通人群长五年

《科学报告》杂志研究表明：太空旅行可以改善睡眠质量并产生潜在的逆转衰老效应

Probiotic Improves Healthspan in Multiple Organisms

Researchers Develop an Anti-Aging CRISPR-Based Gene Therapy

How Does Space Travel Affect Natural Aging?

Late-Life Rapamycin Dosing Regimens Extend Mouse Lifespan in a Sex-Specific Manner

Rapamycin’s Muscle Cell Metabolic Balance Improvement May Enhance Longevity

NAD+ Regulating Enzyme Keeps Mouse Cells Replicating Under Stress

Blood Cancer Therapy May Provide a Strategy for Age-Related Disease Treatments